Ukitumia pombe inasababisha mwili utoe substances known as catecholamines..ambazo zinasababisha activation za nerve system za mpaka kwenye brain
lidocaine ushaanza kuzoe eeeh.nice :thumbup::thumbup:Mkuu upo sahihi..review about brain stem catecholamines circuity activation by alcohol..
also alcohol causes rise of plasma cortisol concenyration and adrenaline which increases heart rate and make some one active.
Mkuu upo sahihi..review about brain stem catecholamines circuity activation by alcohol..
also alcohol causes rise of plasma cortisol concenyration and adrenaline which increases heart rate and make some one active.
mkuu hapo umetudanganya catecholamines zinasababisha activation ya brain which is opposite to what alcohol does to you...
alcohol ni CNS depresant....ina sababisha inhibition ya neurones kwenye ubongo kama vile glutamate na GABA...depression ya alcohol kwenye ubongo ni dose dependent, yaani unapoanza kunywa na kuongeza concetration mdogo mdogo ndipo unapoona hiyo cns depresion...
kwanza unaanza kwa kupata kitu inaitwa paradoxical disinhibition...ambapo hapo unakua kidogo upo active coz umeinhibit gaba neurones ( kwenye ubongo GABA neurones zipo nyingi kuliko glutamate)...
hapo kwenye paradoxical disinhibition unakua umeondoa zile breaks ambazo mtu wa kawaida anakuanazo...mfano kabla hujanywa pombe unakua huezi kuongea matusi kwasababu zile breaks zinakuepo sasa kama zile breaks hazipo hapo ndo mtu anapofeel kujiamini na kufanya mambo ambayo ukiwanormal huezi fanya
then baadae unapozidi kuongeza concetration ndipo unapoanza kuona CNS depression kwa kuinhibit neurones zote yaani gaba pamoja na glutamate..
ndio maana unapokunywa bia yenye concetration nyingi ya alcohol mfano bia bingwa ile iliyofungiwaga waezapata respiratory depression na kudanja mazima kama ukinywa nyingi
Huu uzi wangu ulinipotea asee!
mkuu kureliziwa kwa catecholamines ni reflex mechanism...ambayo ni secondary to CNS depression and metabolic derangement zinazoletwa na alcohol kwenye mwili...
ngoja nikupe mfano utakao kuonyesha jinsi catecholamines zinavyokuwa released na dhumuni lake...
ukinywa pombe.. tukiachana na primary action yake ya kudepress ubongo, zile metabolites za alcohol zinasababisha acidosis kwenye damu..
acidosis kwenye damu itasababisha bradycardia na mambo mengine...ili sasa kucounteract hii reduced heart rate ( bradycardia) brain itaactivate sympathetic nervous system na kurelease noradrenaline na adrenaline ambazo zinaeffect kwenye heart na sehemu nyingine ..
hapo sasa ndo mtu anapopata tachycardia yaani increase in heart rate kama ulivyosema pamoja na increase in plasma cortisol levels nk.. hizi zote zikiwa effect za rise in plasma catecholamines
ila mkuu catecholamines has nothing to do with the feeling of being drunk or anything ...ingekua ni hivyo basi kila tunapopata stress tunalewa...