Rheumatoid Arthritis (RA) Disease
Autoimmune diseases; anti-TNF and biologics medication drugs used for treatment of rheumatic disorders: rheumatoid arthritis (RA), Systemic lupus erythematosus (SLE), drug-induced lupus (DIL), RA vasculitis , Felty’s syndrome, juvenile idiopathic arthritis (JIA), systemic sclerosis (SSc),ANA positive undifferentiated connective tissue diseases, primary biliary cirrhosis and autoimmune hepatitis.
When you see the letters itis at the end of a disease name, it means “inflammation of” The first part of the word indicates the part of the body that is involved in the inflammation process. For example, the word dermatitis means inflammation of the skin (derm), tonsillitis is the inflammation of the tonsil, otitis
inflammation of the ear and arthritis is the inflammation of a joint in the body and so on.
It is important to recognise that immunosuppressant drugs do not cure rheumatoid arthritis, they merely halt the activity of the disease.
in all cases of drug-induced autoimmune diseases described thus far, the disease disappears when the drug is removed.
T-lymphocytes or T cells are one of the first immune cells to become aware of the presence of foreign cells. When they notice that an infection has occurred, they release different classes of immune cofactors, or biochemical signals that activate B cells to produce antibodies and other immune cells.
By using these messages, T cells recruit additional cells and start an immune reaction. Regulatory T cells defend the body by recruiting other cells. These cells “communicate” to one another with immune cofactors, which are small bioactive signals that are produced by cells.
The self-reactive CD4 T-helper cell was recognized as the common critical factor in autoimmune diseases (RA, SLE, MS) and responsible for the translation of induction factors into disease expression and progression through pathways stimulating cellular immune responses (Th1 responses) or autoantibody production (Th2 responses). The disease-modifying anti-rheumatic drug (DMARD) dampen the induction of self-reactive CD4 T-helper cells by limiting their ability to generate Th1 and Th2 responses, and/or interfere with the effector pathways should abrogate the disease.
This is how disease modifying drug treatments reduce RA symptoms.
T-Cell Activation in Rheumatoid Synovium Is B-Cell Dependent. in Autoimmune disease immune system hyperactivity is due to a defect in T-cell homeostasis regulatory.
The articular cartilage in the joint provides a smooth, gliding surface for opposing bone. This is made possible because of the lubrication caused by the synovial fluid. the opposing bones do not wear or erode over time due to the constant friction caused by movement at the joint. Articular cartilage has a limited blood supply. It receives its nourishment from the synovial fluid and from a small number of subsynovial blood vessels at the junction of the cartilage and the joint capsule. Synovial fluid has two functions: creating a smooth gliding surface for opposing bones and nourishing the articular cartilage. Cartilage also functions as a buffer between the vertebrae in the spinal column to minimize the forces of weight and shock from running, walking, or jumping.
Synovial joints have a number of functions. First, they bear weight and allow movement; second, their construction in the form of a capsule made of ligaments, tendons, muscles, and articular cartilage provides stability; and third, synovial fluid lubricates the joint and nourishes the cartilage.
Rheumatoid arthritis is a musculoskeletal disease.
Rheumatoid arthritis affects approximately 1% of the population, or approximately 580,000 people in England. Of these, approximately 15% have severe disease. It is about two- to four-times more prevalent in women than in men. It can develop at any age, but the peak age of onset in the UK is about 40–70 years.
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RA Associated diseases; Pernicious anemia, Cryoglobulinemia, Peripheral neuropathy, Hemolytic anemia, Raynaud syndrome, Thyroid dysfunction, Seronegative arthritis, Scleroderma and Keratoconjunctivitis ( In gout, serum uric acid is elevated). these are all Systemic Vasculitis Syndromes.
Caplan syndrome occurs in patients with rheumatoid arthritis and some form of nodular silicosis.
Systemic Autoimmune Diseases: Immune complexes accumulate in many tissues and cause inflammation and damage.
Systemic Lupus Erythematosus (anti-nuclear antibodies): harms kidneys, heart, brain, lungs, skin…
Rheumatoid Arthritis (anti-IgG antibodies): joints, hand, wrist, fingers, knee, hip….
Rheumatic fever: cross-reaction between antibodies to streptococcus and auto-antibodies.
People with psoriasis may develop other forms of arthritis such as rheumatoid arthritis and osteoarthritis (as long as they are on immunosuppressant drugs).
Cyclophosphamide is also used to treat lupus, vasculitis and myositis. It’s occasionally used for severe rheumatoid arthritis.
The Disease Modifying Anti Rheumatic Drugs (DMARDs) used in Rheumatoid arthritis treatment; D-penicillamine, gold, antimalarials, choloroquine, sulfasalazine, leflunomide, methotrexate. NSAIDs are for symptom relief, but do not prevent disease progression.
Rheumatoid Arthritis Biologic drugs; infliximab, rituximab, etanercept, adalimumab, abatacept, certolizumab, tocilizumab and golimumab (Simponi), Leflunomide. certolizumab pegol (CIMZIA) Injection. Consultant rheumatologist only.
Methotrexate (MTX) is one of the most popular antirheumatic drugs used for treatment of RA.
drugs like procainamide and hydralazine can induce autoantibodies and lupus-like disorders in patients.
The use of Statin drug is associated with a significantly increased risk of rheumatoid arthritis.
Research studies published by the Green Med Info (Evidence-Based Natural Health Resource) has shown that vaccination may contribute to causing a wide variety of autoimmune disorders; RA, SLA, Guillain-Barre Syndrome, Human Papillomavirus (HPV), Inflammatory Myopathy, Macrophagic myofasciitis, Multiple Sclerosis, Vaccine-induced Toxicity, Thrombocytopenia and Vasculitis.
Penicillamine has been associated with myasthenia gravis and a-methyldopa is known to cause a form of haemolytic anaemia.
MTX hepatotoxicity is a common complication of long-term treatment
for rheumatoid arthritis patients.
immunosuppressant drugs do not show benefit on the long term, therefore it seems advisable to try a natural treatment method that requires detoxification of the body and nutrient boost to the immune system.
conventional medicine does not have any healing tool for autoimmune diseases. Antibiotics, the very drug prescribed to fight bacterial infections, also impair the body’s immune system.
A strong natural diet that aims to detoxify the body can very much improve the health of an RA patient ( this is because when the body is intoxicated the immune system is struggling to protect the body from infections ).
Essential fatty acids from fish oil such as EPA and DHA help to balance the immune system as well as act as precursors for vital immune system chemicals thus preventing any progress of Rheumatoid Arthritis.
Dietary fiber directly supports the immune system by stimulating the lymphoid tissue in the gut where 70% of the immune system resides. Fiber also helps to eliminate toxins and increases the number of healthy gut bacteria.
People with autoimmune diseases like RA are advised to attain at least 20-30 minutes of sunshine every day on your entire body in order to produce enough vitamin D.
A list of the best and most trusted doctors on the web:
Dr, Tent - autoimmune diseases and vaccination.
Dr. Mike Adams, Natural Health Nutritions expert - Monopoly Medicine G Edward Griffin Interview.
Dr. Robert O. Young, PH miracle book.
Dr. Kurt Grange, Nutritional biophysiologist
Dr. Joel Wallach, Author; Dead Doctors Don’t Life
Dr. Marcus Laux, Bone disease specialist
Dr. Peter Glidden, nutrient deficiencies expert.
Dr. Gwen Olsen pharma drugs specialist
Dr. Abram Hoffer, Physician, ‘provides nutritional consultations’. auto-immune illnesses, MS causes.
Dr. Carolyn Dean, expert on nutrition - 'The Magnesium Miracle’.
Dr. John Bergman, Autoimmune disease and detox.
Dr. Russell Blaylock, a neurosurgeon. book; Excitotoxins.
Dr. Nikolas Hedberg, Hawthorn University, "Understanding Autoimmune Disease" video related to Systemic Rheumatoid Arthritis.
Dr. Julian Whitaker, Health, Wellness, Vitamins.
Dr. Walter J. Veith, best lectures on 'Dairy Milk & Health dangers’.
Dr. Andrew Thomas Weil, Best adviser on healthy diet and immune system boosting with organic fruits, organic vegetables, and fish. His book 'Why our Health Matters’ focused on health reform through 'Vitamins and Minerals’ (Ask Dr. Weil).
Dr. Mark Sircus, one of the best natural health researcher. Book; 'Sodium Bicarbonate: Nature’s Unique First Aid Remedy’ and 'Transdermal Magnesium Therapy’. Dr George J Georgiou. Founder and director of the Da Vinci College of Holistic Medicine, Doctor of Science (D.Sc).
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Rheumatoid Arthritis (RA) Disease — Autoimmune diseases; anti-TNF and biologics...