Dr Chi
Member
- Dec 20, 2016
- 15
- 16
Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain and inflammation. While effective, it comes with potential risks, especially with long-term or high-dose use. Some key risks include:
1. Cardiovascular Risks Increased risk of heart attack and stroke, especially with prolonged use or in people with existing heart conditions. May cause high blood pressure or worsen existing hypertension.
2. Gastrointestinal (GI) Risks Can cause stomach ulcers, bleeding, and perforation, which can be life-threatening. Higher risk in elderly individuals, heavy drinkers, or those with a history of ulcers.
3. Kidney Damage May lead to kidney failure or worsen preexisting kidney disease, especially in dehydrated individuals or those with heart or liver conditions.
4. Liver Toxicity Can cause liver damage, including hepatitis or liver failure in rare cases. Signs include jaundice (yellowing of skin/eyes), dark urine, or unusual fatigue.
5. Allergic Reactions & Skin Issues Can trigger severe allergic reactions, including rash, swelling, and breathing difficulties. Rare but serious conditions like Stevens-Johnson syndrome (severe skin reaction) may occur.
6. Risk During Pregnancy Not recommended in the third trimester, as it can harm fetal development and cause premature closure of the ductus arteriosus (a blood vessel in the fetus).
7. Drug Interactions May interact negatively with blood thinners, other NSAIDs, diuretics, and certain blood pressure medications, increasing risks of bleeding or kidney problems. Safer Use Recommendations Use the lowest effective dose for the shortest duration possible. Avoid using it in patients with heart disease, ulcers, or kidney problems unless prescribed by a doctor.
Monitor for side effects, especially if taking it long-term.
1. Cardiovascular Risks Increased risk of heart attack and stroke, especially with prolonged use or in people with existing heart conditions. May cause high blood pressure or worsen existing hypertension.
2. Gastrointestinal (GI) Risks Can cause stomach ulcers, bleeding, and perforation, which can be life-threatening. Higher risk in elderly individuals, heavy drinkers, or those with a history of ulcers.
3. Kidney Damage May lead to kidney failure or worsen preexisting kidney disease, especially in dehydrated individuals or those with heart or liver conditions.
4. Liver Toxicity Can cause liver damage, including hepatitis or liver failure in rare cases. Signs include jaundice (yellowing of skin/eyes), dark urine, or unusual fatigue.
5. Allergic Reactions & Skin Issues Can trigger severe allergic reactions, including rash, swelling, and breathing difficulties. Rare but serious conditions like Stevens-Johnson syndrome (severe skin reaction) may occur.
6. Risk During Pregnancy Not recommended in the third trimester, as it can harm fetal development and cause premature closure of the ductus arteriosus (a blood vessel in the fetus).
7. Drug Interactions May interact negatively with blood thinners, other NSAIDs, diuretics, and certain blood pressure medications, increasing risks of bleeding or kidney problems. Safer Use Recommendations Use the lowest effective dose for the shortest duration possible. Avoid using it in patients with heart disease, ulcers, or kidney problems unless prescribed by a doctor.
Monitor for side effects, especially if taking it long-term.
