#COVID19 Ifahamu chanjo ya Johnson & Johnson

#COVID19 Ifahamu chanjo ya Johnson & Johnson

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Hii ni miongoni mwa chanjo zilizo idhinishwa kwaajili ya kukabiliana na madhara ya covid 19.

JINA; JNJ-78436735
WAZALISHAJI: Jansen Pharmaceuticals Companies of Johnson and Johnson

Aina ya chanjo: Viral vector
Full list of ingredients / list ya viungo vilivyotumika hivi vimewekwa katika makundi mawili , ambavyo ni active ingredients/ viungo hai na inactive ingredients / visivyo hai/tuli

Tuanze kundi la kwanza la ingredients

  • Recombinant, replication-incompetent Ad26 vector
  • encoding a stabilized variant of the SARS-COV-2 spikes protein

kundi la pili ni, Pilysorbate-80, 2-hydroxypropyl, cyclodextrin, citric acid monohydrate, trisodium citrate dihydeate, sodium chloride na Ethanol.

Viral vector ninini? tunaweza kusema ni vitu vitumikavyo katika katika molekula -biolojia ambavyo hutoa ghafi za vinasaba kwenda kwenye seli.
VIRAL VECTOR VACCINE ni kitu gani? Ni kundi la chanjo ambalo hutumia virusi vilivyo shushwa hadhi(modified version of a different virus)

viral vector covid -19 vaccines, chanjo hii imetumia matoleo tofauti tofauti ya virusi vilivyoshushwa hadhi (modified) ili kutoa maelekezo muhimu kwenye seli. Faida za chanjo za kundi hili ni kuwa aliyechanjwa hata weza kupata madhara makubwa ya ugonjwa wa covid-19 baada ya kuchanjwa

How it works?
Viral vector vaccine use a modified version of differents virus(the vector) to deliver important information to our cell.
  • The vector (not virus cause covid-19, but a different harmless virus) will enter a cell machinery to produce a harmless piece of the virus that cause Covid -19, this piece is known as a spike protein and its only found on the surfsce of the virus that cause COVID -19.
  • Next, the cell display the spike protein on its surface and our immune system recognized if does belong there. this trigger our immune system to begin producing antibodies and activating other immune cell to fight off what it thinks is an infection.
-At the end process our bodies have learned how to protect us against future infections with the virus that cause Covid -19.

Kwa ufupi ni kuwa J&J ni miongoni mwa chanjo zilizotengenezwa kwa virusi dhaifu, ambavyo havina madhara mfano hapo tumeona matumizi ya SARS-2, lakini vinavyofanan na vile vya covid -19 ambapo virus hivi dhaifu vinapowekwa kwenye seli hutumia mitambo seli kuzalisha virusi vya COVID-19 visivyo na madhara ambavyo huchukuliwa kuwa ni spike protein na huchukua mahali pale ambapo virusi vya hatari vya corona hukaa baada ya hapo husababisha mfumo wa immune kuanza kuzalisha antibodi na kushtua seli za immune kuanza kupigana na hiki kinachodhaniwa kuwa ni maambukizi, na baada ya hapo mwili hujifunza kukabiliana na maambukizi yanayosababishwa na Covid 19, ile active sasa.

FACTS
  • VACCINE kama J&J haiwezi kukusababishia virusi vya covid -19
  • Haiwezi kuingiliana na mifumo ya DNA

Inapendekezwa kutumiwa na watu wenye umri 18+

SIDE EFFECT KWA UJUMLA
Kwenye eneo unapochomwa, maumivu, pekundu, uvimbe
PAIN, REDNESS, SWELLING

Mwilini - mchoko, maumivu ya kichwa, maumivu ya misuli, ubarid, homa , kichefu chefu
Tiredness, HEADACHE, MUSCLE PPAIN, chills, fever &nausea
nb. ATHARI HIZI SIO LAZIMA NA ZINAPOJITOKEZA KWA MUDA WA ZAIDI YA SAA 24 UNASHAURIWA KUMWONA DAKTARI.

TAARIFA ZA CLINIC YA MAJARIBIO YA CHANJO YA JOHNSON AND JOHNSON
chanjo hii ilionesha ufanisi wa asilimia 66.3 katika maabara za utafiti na ilionesha uwezo mkubwa katika kukabliana na ugonjwa huu.

Clinical Demographic information
Utafiti ulihusisha racial, etnic, age na sex catogories
- 62% White
-17% black or African Amercan
-8% Amerca indian or Alaska natives
-5% multiple race
-4% Asia
-0.3% Native hawaiian or other pacific Islander

Ethnicity
  • 45% Hispanic or latino
  • 52% non Hispanic or latino
  • 3% unknown

SEX
56% MALE
45% FEMALE
0.1% UNKNOWN SEX
Age breckdown, 67% 18_59 yrs
34% 60+
20% 65 yrs and +, 4%, 75 yrs

CHANZO KIKUU CHA TAARIFA KATIKA MAKALA HII NI CDC, centers for Disease conrol and prevention na maandiko mengineyo

 
Ingekuwa vizuri ungeweka ushahidi mkuu. Tunahitaji maarifa yaliyothibitika
Angalia idadi ya waliotumia Johnson and Johnson kwa nchi ya Marekani nadhani utapata jibu
Screenshot_20210728-165927_1.jpg
 
inaweza kuwa kweli lakini tujue kule wao wameidhinisha chanjo kibao na watu wanauhuru wakulinganisha na kuona ile inayowafaa zaidi
Sio inaweza kuwa kweli Bali ni kweli. Yes wameidhinisha chanjo kibao, ila unafikiri kwa nini wengi hawatumii Johnson and Johnson? Angalia hili jedwali chini uone idadi ya waliotumia hii Johnson and Johnson, nadhani utapata jibu
Screenshot_20210728-165927_1.jpg
 


Johnson & Johnson​

On February 27, 2021, the FDA granted emergency use approval for a different type of vaccine, called a carrier, or virus vector, vaccine. In comparison to the Pfizer and Moderna vaccines, this one is easier to store (in refrigerator temperature), and requires only a single shot, which has made it easier to distribute and administer. An analysis released by the FDA in late February showed that the vaccine may reduce the spread of the virus by vaccinated people.

The Food and Drug Administration (FDA) has attached two warnings to the Johnson & Johnson vaccine. In July, it attached a warning after rare cases of the neurological disorder Guillain-Barré syndrome were reported in a small number of vaccination recipients. Most of the cases occurred within 42 days after vaccination. In April, the FDA added a warning label after ending a pause on the vaccine it had recommended “out of an abundance of caution” over an uncommon, but potentially serious, blood clotting disorder occurred in a small number of recipients.

Status: Emergency use in the U.S.; authorized for use in the European Union (under the name Janssen).

Recommended for: Adults 18 and older.

Dosage: Single shot. In November, Johnson & Johnson announced it would launch a second Phase 3 clinical trial to study using two doses, two months apart, to see if that regimen will provide better protection.

Common side effects: Fatigue, fever headache, injection site pain, or myalgia (pain in a muscle or group of muscles), all of which generally resolve within a day or two. It has had noticeably milder side effects than the Pfizer and Moderna vaccines, according to the FDA report released in late February. No one suffered an allergic reaction in clinical trials for the vaccine, according to the company.

How it works: This is a carrier vaccine, which uses a different approach than the mRNA vaccines to instruct human cells to make the SARS CoV-2 spike protein. Scientists engineer a harmless adenovirus (a common virus that, when not inactivated, can cause colds, bronchitis, and other illnesses) as a shell to carry genetic code on the spike proteins to the cells (similar to a Trojan Horse). The shell and the code can’t make you sick, but once the code is inside the cells, the cells produce a spike protein to train the body’s immune system, which creates antibodies and memory cells to protect against an actual SARS-CoV-2 infection.

How well it works: 72% overall efficacy and 86% efficacy against severe disease in the U.S.

How well it works on virus mutations: This vaccine’s effectiveness has been shown to offer protection against the Alpha variant. According to the analyses the FDA released in late February, there was 64% overall efficacy and 82% efficacy against severe disease in South Africa, where the Beta variant was first detected. Johnson & Johnson reported in July that its vaccine is also effective against the Delta variant, showing only a small drop in potency compared with its effectiveness against the original strain of the virus. Although one recent study, which has not yet been peer-reviewed or published in a scientific journal, suggests that the J&J vaccine is less effective against Delta
 

Johnson & Johnson​

On February 27, 2021, the FDA granted emergency use approval for a different type of vaccine, called a carrier, or virus vector, vaccine. In comparison to the Pfizer and Moderna vaccines, this one is easier to store (in refrigerator temperature), and requires only a single shot, which has made it easier to distribute and administer. An analysis released by the FDA in late February showed that the vaccine may reduce the spread of the virus by vaccinated people.

The Food and Drug Administration (FDA) has attached two warnings to the Johnson & Johnson vaccine. In July, it attached a warning after rare cases of the neurological disorder Guillain-Barré syndrome were reported in a small number of vaccination recipients. Most of the cases occurred within 42 days after vaccination. In April, the FDA added a warning label after ending a pause on the vaccine it had recommended “out of an abundance of caution” over an uncommon, but potentially serious, blood clotting disorder occurred in a small number of recipients.

Status: Emergency use in the U.S.; authorized for use in the European Union (under the name Janssen).

Recommended for: Adults 18 and older.

Dosage: Single shot. In November, Johnson & Johnson announced it would launch a second Phase 3 clinical trial to study using two doses, two months apart, to see if that regimen will provide better protection.

Common side effects: Fatigue, fever headache, injection site pain, or myalgia (pain in a muscle or group of muscles), all of which generally resolve within a day or two. It has had noticeably milder side effects than the Pfizer and Moderna vaccines, according to the FDA report released in late February. No one suffered an allergic reaction in clinical trials for the vaccine, according to the company.

How it works: This is a carrier vaccine, which uses a different approach than the mRNA vaccines to instruct human cells to make the SARS CoV-2 spike protein. Scientists engineer a harmless adenovirus (a common virus that, when not inactivated, can cause colds, bronchitis, and other illnesses) as a shell to carry genetic code on the spike proteins to the cells (similar to a Trojan Horse). The shell and the code can’t make you sick, but once the code is inside the cells, the cells produce a spike protein to train the body’s immune system, which creates antibodies and memory cells to protect against an actual SARS-CoV-2 infection.

How well it works: 72% overall efficacy and 86% efficacy against severe disease in the U.S.

How well it works on virus mutations: This vaccine’s effectiveness has been shown to offer protection against the Alpha variant. According to the analyses the FDA released in late February, there was 64% overall efficacy and 82% efficacy against severe disease in South Africa, where the Beta variant was first detected. Johnson & Johnson reported in July that its vaccine is also effective against the Delta variant, showing only a small drop in potency compared with its effectiveness against the original strain of the virus. Although one recent study, which has not yet been peer-reviewed or published in a scientific journal, suggests that the J&J vaccine is less effective against Delta
shukrani mkuu pita na hapa mkuu unipepo vote>>Story of Change - Unavyoweza kujiajiri kwa kufundisha mtandaoni
 
Hii ni miongoni mwa chanjo zilizo idhinishwa kwaajili ya kukabiliana na madhara ya covid 19

JINA; JNJ-78436735
WAZALISHAJI: Jansen Pharmaceuticals Companies of Johnson and Johnson

Aina ya chanjo: Viral vector
Full list of ingredients / list ya viungo vilivyotumika hivi vimewekwa katika makundi mawili , ambavyo ni active ingredients/ viungo hai na inactive ingredients / visivyo hai/tuli

Tuanze kundi la kwanza la ingredients

  • Recombinant, replication-incompetent Ad26 vector
  • encoding a stabilized variant of the SARS-COV-2 spikes protein

kundi la pili ni, Pilysorbate-80, 2-hydroxypropyl, cyclodextrin, citric acid monohydrate, trisodium citrate dihydeate, sodium chloride na Ethanol.

Viral vector ninini? tunaweza kusema ni vitu vitumikavyo katika katika molekula -biolojia ambavyo hutoa ghafi za vinasaba kwenda kwenye seli.
VIRAL VECTOR VACCINE ni kitu gani? Ni kundi la chanjo ambalo hutumia virusi vilivyo shushwa hadhi(modified version of a different virus)

viral vector covid -19 vaccines, chanjo hii imetumia matoleo tofauti tofauti ya virusi vilivyoshushwa hadhi (modified) ili kutoa maelekezo muhimu kwenye seli. Faida za chanjo za kundi hili ni kuwa aliyechanjwa hata weza kupata madhara makubwa ya ugonjwa wa covid-19 baada ya kuchanjwa

How it works?
Viral vector vaccine use a modified version of differents virus(the vector) to deliver important information to our cell.
  • The vector (not virus cause covid-19, but a different harmless virus) will enter a cell machinery to produce a harmless piece of the virus that cause Covid -19, this piece is known as a spike protein and its only found on the surfsce of the virus that cause COVID -19.
  • Next, the cell display the spike protein on its surface and our immune system recognized if does belong there. this trigger our immune system to begin producing antibodies and activating other immune cell to fight off what it thinks is an infection.
-At the end process our bodies have learned how to protect us against future infections with the virus that cause Covid -19.

Kwa ufupi ni kuwa J&J ni miongoni mwa chanjo zilizotengenezwa kwa virusi dhaifu, ambavyo havina madhara mfano hapo tumeona matumizi ya SARS-2, lakini vinavyofanan na vile vya covid -19 ambapo virus hivi dhaifu vinapowekwa kwenye seli hutumia mitambo seli kuzalisha virusi vya COVID-19 visivyo na madhara ambavyo huchukuliwa kuwa ni spike protein na huchukua mahali pale ambapo virusi vya hatari vya corona hukaa baada ya hapo husababisha mfumo wa immune kuanza kuzalisha antibodi na kushtua seli za immune kuanza kupigana na hiki kinachodhaniwa kuwa ni maambukizi, na baada ya hapo mwili hujifunza kukabiliana na maambukizi yanayosababishwa na Covid 19, ile active sasa.

FACTS
  • VACCINE kama J&J haiwezi kukusababishia virusi vya covid -19
  • Haiwezi kuingiliana na mifumo ya DNA

Inapendekezwa kutumiwa na watu wenye umri 18+

SIDE EFFECT KWA UJUMLA
Kwenye eneo unapochomwa, maumivu, pekundu, uvimbe
PAIN, REDNESS, SWELLING

Mwilini - mchoko, maumivu ya kichwa, maumivu ya misuli, ubarid, homa , kichefu chefu
Tiredness, HEADACHE, MUSCLE PPAIN, chills, fever &nausea
nb. ATHARI HIZI SIO LAZIMA NA ZINAPOJITOKEZA KWA MUDA WA ZAIDI YA SAA 24 UNASHAURIWA KUMWONA DAKTARI.

TAARIFA ZA CLINIC YA MAJARIBIO YA CHANJO YA JOHNSON AND JOHNSON
chanjo hii ilionesha ufanisi wa asilimia 66.3 katika maabara za utafiti na ilionesha uwezo mkubwa katika kukabliana na ugonjwa huu.

Clinical Demographic information
Utafiti ulihusisha racial, etnic, age na sex catogories
- 62% White
-17% black or African Amercan
-8% Amerca indian or Alaska natives
-5% multiple race
-4% Asia
-0.3% Native hawaiian or other pacific Islander

Ethnicity
  • 45% Hispanic or latino
  • 52% non Hispanic or latino
  • 3% unknown

SEX
56% MALE
45% FEMALE
0.1% UNKNOWN SEX
Age breckdown, 67% 18_59 yrs
34% 60+
20% 65 yrs and +, 4%, 75 yrs

CHANZO KIKUU CHA TAARIFA KATIKA MAKALA HII NI CDC, centers for Disease conrol and prevention na maandiko mengineyo

Nauliza , chanjo hii ni ya majaribio?
 
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