(1) The Great Carthaginian Commander Hannibal [247-182 BCE] defeated a Roman Army, in one of the largest and most successful ambushes in military history, and one of the worst defeats ever inflicted on a Roman army. It is one of the standard examples of ambush tactics, still studied by all students of military history today.
Hannibal lured the Roman Army into a narrow defile, with the lake on one side and hills on the other, blocked both ends of the Roman column and destroyed it. This was one of three major & historically famous victories won by Hannibal against the Romans, during the 2nd Punic War (218-201 BCE) between the Roman Republic and Carthage, for domination of the Mediterranean Sea.
(2) Exiled from his home of Carthage, the Great General, Hannibal found himself leading the Bithynian fleet against the superior force of the Pergamon navy - an ally of his old nemesis, Rome.
In the days before the battle, knowing he would be outnumbered, Hannibal directed his men to gather up as many venomous snakes as they could find and put them in clay jars.
As the battle commenced, Hannibal ordered his men to concentrate their entire efforts on just one of the 425 enemy ships - that which carried the Pergamenian King, Eumenes II.
The Bithynian fleet catapulted a vast quantity of their newly invented snake bombs at the ship. In terror Eumenes II fled the battle and "startled at the strangeness of the occurrence" his fleet followed him back to their coastal camp.
Hannibal not only won the day but successfully demonstrated an early version of biological warfare.
(3) Hannibal occupied Southern Italy for 15 years and the Romans avoided direct confrontation with him for that entirety.