Malaika wa Kifo
JF-Expert Member
- Apr 11, 2012
- 4,052
- 4,621
Huyu jamaa nimemkumbuka baada ya kuona huu uzi, nikienda nitamtafuta niongee nae
Koboko (Black Mamba) - Nyoka hatari zaidi duniani
Koboko (Black Mamba) - Nyoka hatari zaidi duniani
Black Sniper
JF-Expert Member
- Dec 10, 2013
- 32,406
- 55,148
Kama dawa inatibu vizuri bora umsaidie kwa kweli
Na wewe utajifunza zaidi
Siku hizi ulimwengu upo kiganjani
Ukihitaji tu ni click tu
Kichogo
JF-Expert Member
- Jun 10, 2016
- 2,094
- 3,218
Huyu kwel mkomavu hivi nyoka hua wanatumia zaid pua au macho kwenye harakat zao zauwindaj mana nasika et hawasikii
Kichogo
JF-Expert Member
- Jun 10, 2016
- 2,094
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Halafu huyu msela anaonekana anangozi ngum asee yan magamba kama kobe
Kichogo
JF-Expert Member
- Jun 10, 2016
- 2,094
- 3,218
Duu shkamoo mkuu japo nkiweka mambo sawa darasa latano ilikua 2002, nadhan mitaala imebadilika nahata saiv mashulen hakitumiki, enzi nlisoma neno koboko nasikuelewa ninin saiv ndo naelewa kwel elim haina mwisho mkuu
Kichogo
JF-Expert Member
- Jun 10, 2016
- 2,094
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Umenkumbusha mbali asee unakuta mko pori halafu kitu cha ubwabwa kinanukia, hua tunamin ukisikia harufu hio ujue joka linajichuna gamba
mkulungu mkuyengo
JF-Expert Member
- Feb 5, 2015
- 786
- 564
kuna ka story kuhusu black mamba hujatupia link ya youtube im waiting for that.
imhotep
JF-Expert Member
- Oct 13, 2012
- 55,997
- 88,219
Inaaminika kuwa Koboko ni Solitary, lakini tukio lililotokea huko Pokot Kenya lilishangaza wengi, Koboko wawili walipo mshambulia mama mmoja bila sababu zozote
imhotep
JF-Expert Member
- Oct 13, 2012
- 55,997
- 88,219
Basi utakuwa Ophidiophobic,uoga wa Nyoka kupita kiasi.
imhotep
JF-Expert Member
- Oct 13, 2012
- 55,997
- 88,219
Nyoka husikia kivyao sio viziwi kabisa kama baadhi ya watu wanavyoamini,kuna baadhi ya nyoka wanaona mpaka kwenye giza,kitu ambacho binaadamu wamegundua juzijuzi,halafu nyoka anatumia ulimi wake kulamba harufu vizuri kuliko pua zetu.
kat.ph
JF-Expert Member
- Dec 19, 2013
- 2,222
- 1,678
Hahahahhaha hapa hamna kabisa. Kukwepa makoboko karibu sana kununua kiwanja hapa
Black Sniper
JF-Expert Member
- Dec 10, 2013
- 32,406
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Asante boss
imhotep
JF-Expert Member
- Oct 13, 2012
- 55,997
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The nature paper published today by Sylvie Diochot, from the Institut de Pharmacologie Mole´culaire et Cellulaire in France, and colleagues describes two black mamba venom toxin components (mambalgins) that block acid-sensing ion channels (ASICs) in peripheral, pain-sensing nerves and central pain pathways.
These toxins exert profound analgesic effects in mouse models of pain by blocking ASIC in these two pathways via both an opioid-dependent and opioid-independent pathway. Even the opioid-independent mechanism has the same strong effect as that of opioids such as morphine.
The new opioid-independent pain-killing mechanism is very interesting, because it may reduce the risk from overdoses that cause respiratory depression – the most dangerous form of opioid overdose. It may also reduce the risk of addiction associated with opioid drugs.
Pain responses in animals can be due to drowsiness or muscle relaxation caused by the agent being tested. According to the authors, the experiments described in the paper show no signs of these confounding effects that could give a false impression of pain-killing action.
From this paper, it looks like the black mamba toxin may contain a new component, mambalgin, that can be used to develop new pain therapies.
What happens now?
It’s possible, but unlikely, that one of the mambalgin proteins identified will be used as medicine without any more changes being made to it.
But pharmaceutical companies and publicly funded research groups will probably look for small molecules that can mimic the actions of mambalgins to produce potent, orally available drugs to treat pain. Unfortunately, this process could take up to ten years to complete.
Pain is poorly treated currently and there is a dire need for new and more effective drugs to improve the quality of life of people with pain.
So, we should wish these research groups the best of luck!
These toxins exert profound analgesic effects in mouse models of pain by blocking ASIC in these two pathways via both an opioid-dependent and opioid-independent pathway. Even the opioid-independent mechanism has the same strong effect as that of opioids such as morphine.
The new opioid-independent pain-killing mechanism is very interesting, because it may reduce the risk from overdoses that cause respiratory depression – the most dangerous form of opioid overdose. It may also reduce the risk of addiction associated with opioid drugs.
Pain responses in animals can be due to drowsiness or muscle relaxation caused by the agent being tested. According to the authors, the experiments described in the paper show no signs of these confounding effects that could give a false impression of pain-killing action.
From this paper, it looks like the black mamba toxin may contain a new component, mambalgin, that can be used to develop new pain therapies.
What happens now?
It’s possible, but unlikely, that one of the mambalgin proteins identified will be used as medicine without any more changes being made to it.
But pharmaceutical companies and publicly funded research groups will probably look for small molecules that can mimic the actions of mambalgins to produce potent, orally available drugs to treat pain. Unfortunately, this process could take up to ten years to complete.
Pain is poorly treated currently and there is a dire need for new and more effective drugs to improve the quality of life of people with pain.
So, we should wish these research groups the best of luck!
Philosodilia
Senior Member
- Jan 25, 2018
- 105
- 61
Naomba kuuliza kidogo...
Hivi wale rafiki zetu "Ni hao" hawamli huyu jamaa?!
Hivi wale rafiki zetu "Ni hao" hawamli huyu jamaa?!
rip faza_nelly
JF-Expert Member
- Feb 19, 2018
- 5,749
- 7,038
Eti 'ni hao'......nyauuuu[emoji3] [emoji3] [emoji3] [emoji3] [emoji3]
kivyako
JF-Expert Member
- Feb 2, 2012
- 14,340
- 12,055
Napenda kuwaona kama kwenye zoo ila sio kuwagusa
kivyako
JF-Expert Member
- Feb 2, 2012
- 14,340
- 12,055
Nimecheki maisha ya Steve Irwin (Australia), dah so shocking! Jamaa alikuwa na roho ngumu kucheza na wadudu wa dizaini, japo alikuja kuuawa na samaki jamii ya shark!