Taasisi za afya za utafiti za Tanzania zinaendeshwa kiudalali, kiujanja-ujanja na kimchongo

[Dennis Robert Shughuru]

Sitazitaja majina hizi taasisi zetu., nyingi sana nimeshawahi kuzipelekea proposal za project wengi walikuwa wanashangaa proposal nilizokuwa nawapelekea, wengine unaambiwa appointment ndo imetoka hiyo ni full ubabishaji naandika haya nikiwa ni mtu ambaye nina-uzoefu wa kukataliwa na hizi taasisi

bali huu ni ukweli mchungu taasisi za afya za Tanzania kwa asilimia kubwa zinaendeshwa kiujanjaujanja kwanini nasema hivi

1. Nyingi zinatumika kukusanya data kwa ajili ya makampuni ya wazungu inshort nyingi ni middleman (madalali)
2. Hata tafiti ambazo wanafanya kwenye issue ya drug discovery zimejikita kwenye drug reposition moja ya field ya watu wavivu
3. Ukiwapelekea idea za kutengeneza dawa wanazipiga chini haraka sana bila hata kuuliza, yaani wao kwenye akili zao wameshakubali kushindwa ila bado wanangangania kufanya kazi kwenye hizo taasisi wanashangaza sana
4. Wafanyakazi wanapigania familia zao kupitia hizo taasisi hawana uchungu hata kidogo
5. Nyingi zinatumika na madalali wanaoishi nchi za western kama sehemu za michongo refer issue ya USAID
6. Wanafanya mambo ya kawaida sana nyingine zina-majina makubwa sana ila wanafanya mambo ya kawaida sana
7. Kwa sababu zinaendeshwa kimchongomchongo hazina malengo ya maana ya mda mfupi na mrefu

Kuna watakaosema serikali zetu za kiafrika haziweki fedha ya kutosha kwenye taafiti ni kweli ila tatizo linaanzia kwa hao Wafanyakazi wa kwenye hizo taasisi wengi wao wanapigania familia zao, malengo yao binafsi kupitia hizo taasisi

• Wengi wanafurahia paper zao kuchapishwa kwenye journal za nchi za Western-na huu utumwa ndo unaotufanya akili zetu ziwe kwenye gereza hatuwezi fanya kitu mpaka tuwapelekee wao kwanza waa-approval kwanini tusianzishe journal zetu
• Nieleweke sipingi ushirikiano na nchi za Western bali napinga utumwa wa fikra

Mfano tokea zaman sana ugonjwa wa ebola unatesa waafrika wenzetu lakin mda huo huo kuna mtu bila aibu anajiita mtaafiti na yupo kwenye taasisi flani

Mwaka 2019 imetokea Corona wenzetu wanahangaika na kuja na dawa watafiti wetu wapo kama onlookers ile ilikuwa fedheha kubwa sana baadae yaani tunasubiria huruma na fungulia mbwa ya dawa ambazo zilikuwa zinakaribia kuexpire haya mambo inabidi yafike mwisho

Na kwenye hizo taasisi ni bora kuliko ukutane na wale wazee watatoa mda wao watakusikiliza hata, ila vijana walioajiriwa kwenye hizo taasisi asilimia kubwa sana ni watu wa hovyo sana na hopeless

Lazima taasisi zetu ziwe results oriented life science na pharmaceutical zina-fedha sana kama ukiwa na result au products, kuna watu kwenye hizi taasisi wanasafari sana lakin safari zao hazijawa na tija na faida kwenye hizi taasisi na nchi kwa ujumla yaani zimekuwa ni kama vacation hii inatakiwa istop kama kweli tunataka kupata faida kutoka kwenye life science na pharmaceutical research

NIKIWA RAIS WA TANZANIA HIZI TAASISI ZITAKUWA RESULT ORIENTED NA SIO VACATION ORIENTED KWANINI NAZIITA VACATION ORIENTED HAWAJI NA PRODUCTS ITAKAYO TATUA CHANGAMOTO DUNIANI

 

[Lamine yamal UDOM]

Mkuu,ulikuta taasisi gani ya afya imejaa,wakakunyima ajira?

 

[Dennis Robert Shughuru]

Mkuu,ulikuta taasisi gani ya afya imejaa,wakakunyima ajira?

Nilikuwa sitafuti ajira hata ni mambo ya utafiti

 

[oladipo]

Nilimskiliza polepole alizungumzia the same thing... sekta ya afya imejaa madalali wanaopigania maslai ya mabwana zao

 

[The Knowledge Seeker]

Utaona mtu kaja na tafiti binafsi na kuweka fact zake binafsi, ila atakuja mtu na fact za mwenzake kuzi validate halafu mtu huyuhuyo anaji consider anaelimu na ameelimiaka

 

[Dennis Robert Shughuru]

Utaona mtu kaja na tafiti binafsi na kuweka fact zake binafsi, ila atakuja mtu na fact za mwenzake kuzi validate halafu mtu huyuhuyo anaji consider anaelimu na ameelimiaka

Ndo hao wamejikita kwenye drug repositioning

 

[annatee]

Point namna 3 ndio inadhihirisha ujinga wa Waafrika

 

[Dennis Robert Shughuru]

Point namna 3 ndio inadhihirisha ujinga wa Waafrika

Ni mambo ya ajabu sana

 

[Lamine yamal UDOM]

Nilikuwa sitafuti ajira hata ni mambo ya utafiti

kama ni utafiti,kweli waafrika bado sana kwenye taasisi zetu.

 

[Ngwathra]

Kabla ya huo utafiti wako, unajua costs za kujenga kiwanda cha madawa kijana? Tena chenye uwezo wa kuzalisha na high tech biologics kama mRNa na cell therapy?

Au hiyo maabara ya kufanyia utafiti wako unaijua ilipo? 😀

Rais kwanza ushapata mke? Busu la Kenge

 

[Dennis Robert Shughuru]

Kabla ya huo utafiti wako, unajua costs za kujenga kiwanda cha madawa kijana? Tena chenye uwezo wa kuzalisha na high tech biologics kama mRNa na cell therapy?

Au hiyo maabara ya kufanyia utafiti wako unaijua ilipo? 😀

Rais kwanza ushapata mke? Busu la Kenge

Hivi ndo vitisho waafrika wanapewa kila siku na kupitia hivi vitisho wanashindwa kufanya mambo mengi sana

hakuna jambo rahisi huku duniani ndo maana lazima tuwe na watu wapiganaji kwenye hizi taasis

 

[Ngwathra]

Hivi ndo vitisho waafrika wanapewa kila siku na kupitia hivi vitisho wanashindwa kufanya mambo mengi sana

hakuna jambo rahisi huku duniani ndo maana lazima tuwe na watu wapiganaji kwenye hizi taasis

The investment required to build a fully functioning drug manufacturing facility can vary massively, depending on a number of critical factors. Here’s a breakdown to help contextualize the potential costs:

---

💡 Quick Summary Estimates​

Type of Facility	Estimated Cost (USD)
Small-scale pilot plant (non-GMP)	$1M – $5M
Medium-scale GMP facility	$10M – $50M
Full-scale commercial GMP facility	$50M – $500M+
High-tech biologics facility (e.g. for mRNA, cell therapy)	$100M – $1B+

---

🧪 Key Cost Drivers​

1. Type of Drugs Produced
   • Tablets/capsules (solid dosage): Less expensive
   • Injectables/sterile products: Much more expensive (clean rooms, sterility)
   • Biologics or biosimilars: Extremely high-cost (fermentation, purification, cold chain)
   • Controlled substances: Higher security and regulatory needs
2. Production Scale
   • Pilot (R&D or clinical batches)
   • Mid-size (regional supply)
   • Full commercial scale (global supply)
3. GMP Compliance
   • Compliance with FDA, EMA, WHO, or local authorities can significantly increase costs.
4. Geographic Location
   • Labor, materials, utilities, and regulation costs vary by country.
   • Example: India or China might be 30–70% cheaper than the US or EU.
5. Infrastructure & Utilities
   • HVAC systems (especially for sterile environments)
   • Water-for-injection (WFI), clean steam, compressed air
   • Waste treatment, energy backup systems
6. Automation & Tech
   • Manual vs semi-automated vs fully automated lines
   • Use of robotics, AI for QC, or electronic batch records adds cost
7. Time to Build
   • 18 to 36 months is typical for a GMP-compliant facility

---

📊 Real-World Examples​

• Pfizer’s gene therapy plant (North Carolina, US): ~$600 million
• Biocon biologics facility (India): ~$275 million
• Generic oral solid dosage facility (India): $10–20 million
• Sterile injectable plant (EU): $50–150 million

---

💼 What’s Included in the Investment?​

• Facility design and construction
• HVAC, cleanroom systems
• Production equipment
• Quality control labs (analytical chemistry, microbiology)
• IT systems (LIMS, ERP)
• Regulatory and validation activities
• Hiring and training staff
• Licensing and inspections

---

✅ Bonus: Cost-Saving Options​

• Contract Manufacturing (CDMOs): Avoid CapEx altogether
• Modular/Prefab Facilities: Can reduce cost and time by 20–40%
• Refurbished Equipment: Often used by generics manufacturers
• Location Arbitrage: Set up in countries with lower regulatory and labor costs

---

Would you like a custom estimate based on a specific type of drug (e.g. tablets vs biologics) and country (e.g. US, India, etc.)?

Hayo madafu ya mama aache kubebea kenge kwnye matrekta kuwapaleka kwa mikutani yake kule uswekeni afanye investment ya hivi halafu "rais" ukafanye utafiti wako na kuzalishia mitishamba? Hebu kuwa serious kijana!

 

[Dennis Robert Shughuru]

The investment required to build a fully functioning drug manufacturing facility can vary massively, depending on a number of critical factors. Here’s a breakdown to help contextualize the potential costs:

---

💡 Quick Summary Estimates​

Type of Facility	Estimated Cost (USD)
Small-scale pilot plant (non-GMP)	$1M – $5M
Medium-scale GMP facility	$10M – $50M
Full-scale commercial GMP facility	$50M – $500M+
High-tech biologics facility (e.g. for mRNA, cell therapy)	$100M – $1B+

---

🧪 Key Cost Drivers​

1. Type of Drugs Produced
   • Tablets/capsules (solid dosage): Less expensive
   • Injectables/sterile products: Much more expensive (clean rooms, sterility)
   • Biologics or biosimilars: Extremely high-cost (fermentation, purification, cold chain)
   • Controlled substances: Higher security and regulatory needs
2. Production Scale
   • Pilot (R&D or clinical batches)
   • Mid-size (regional supply)
   • Full commercial scale (global supply)
3. GMP Compliance
   • Compliance with FDA, EMA, WHO, or local authorities can significantly increase costs.
4. Geographic Location
   • Labor, materials, utilities, and regulation costs vary by country.
   • Example: India or China might be 30–70% cheaper than the US or EU.
5. Infrastructure & Utilities
   • HVAC systems (especially for sterile environments)
   • Water-for-injection (WFI), clean steam, compressed air
   • Waste treatment, energy backup systems
6. Automation & Tech
   • Manual vs semi-automated vs fully automated lines
   • Use of robotics, AI for QC, or electronic batch records adds cost
7. Time to Build
   • 18 to 36 months is typical for a GMP-compliant facility

---

📊 Real-World Examples​

• Pfizer’s gene therapy plant (North Carolina, US): ~$600 million
• Biocon biologics facility (India): ~$275 million
• Generic oral solid dosage facility (India): $10–20 million
• Sterile injectable plant (EU): $50–150 million

---

💼 What’s Included in the Investment?​

• Facility design and construction
• HVAC, cleanroom systems
• Production equipment
• Quality control labs (analytical chemistry, microbiology)
• IT systems (LIMS, ERP)
• Regulatory and validation activities
• Hiring and training staff
• Licensing and inspections

---

✅ Bonus: Cost-Saving Options​

• Contract Manufacturing (CDMOs): Avoid CapEx altogether
• Modular/Prefab Facilities: Can reduce cost and time by 20–40%
• Refurbished Equipment: Often used by generics manufacturers
• Location Arbitrage: Set up in countries with lower regulatory and labor costs

---

Would you like a custom estimate based on a specific type of drug (e.g. tablets vs biologics) and country (e.g. US, India, etc.)?

Hayo madafu ya mama aache kubebea kenge kwnye matrekta kuwapaleka kwa mikutani yake kule uswekeni afanye investment ya hivi halafu "rais" ukafanye utafiti wako na kuzalishia mitishamba? Hebu kuwa serious kijana!

Hizo gharama nazijua fahamu unaongea na mtu anajua anachoongea

Gharama haipo kwenye kujenga hizo facility bali kwenye kuja na products hii ndo sehemu ngumu na sio kwenye kujenga hayo majumba

 

[Zemanda]

Nilikuwa natamani sana kukutana na andiko la namna hii na leo nimeliona.

Nakumbuka magufuri alimtimua yule dada (mtoto wa malechela nadhani) ambaye alilopoti taarifa ya ugonjwa fulani wa kichwa kidogo kwa watoto nimesahau jina pia. Watu walilalamika sana ila hawakujua magufuri aliona nini kinaendelea kiutendaji na dada alikuwa na kiburi kweli kweli siku chache baada ya kutumbuliwa akaenda kufanya kazi umoja wa mataifa it means alikuwa na mawasiliano ya karibu sana na watu wa mataifa ya magharibi na pengine alikuwa anakula nao deals za kupitisha ripoti na mapendekezo ya kitaalamu kuhusu magonjwa mbali mbali.

Mwingine ni yuke kipindi cha Corona plandemic (sio pandemic). Alikuwa mkuu wa maabara pale alikuwa anafanya kazi kwa mujibu wa matakwa na mapendekezo yake. Magufuri hakumchelewesha akamlamba ngwala.

Leo hii nadhani alirudishwa tena kazini bila shida. Yule mwingine aliyekwenda umoja wa mataifa sijui alifariki sina uhakika but last time nilisikia msiba wake.

So it's true tuna shida hilo eneo la maabara na tafiti za kitaifa.

Nadhani mbeleni tunatazamia kuwa na makampuni binafsi ya kitafiti ambayo yatashindana kufanya tafiti bora na kutoa ripoti accurate ambazo hazijachakachuliwa na kusaidia kupata majibu ndani ya muda mfupi bila chenga chenga za kipuuzi.

Lakini sio eneo hilo tu,sehemu nyingine nina mashaka nayo sana ni Taasisi ya takwimu ya taifa. Wale jamaa nina mashaka nao sana.

Sijajua kama wamenyooka vizuri katika utunzaji wa takwimu kwa usahihi.

 

[Zemanda]

kama ni utafiti,kweli waafrika bado sana kwenye taasisi zetu.

Imagine hadi leo tunapambana na maralia kwa chandarua na dawa ya mseto au Metakelfin wakati ni ugonjwa unaoweza kutokomezeka kwa urahisi kabisa na kupunguza gharama kwa serikali na raia kwa asilimia 100%. Zero maralia inawezekana ila jamaa wanapambana kila siku maralia iendelee kusababisha vifo na mateso kwa watu.

Shenzi sana hawa.

 

[Zemanda]

The investment required to build a fully functioning drug manufacturing facility can vary massively, depending on a number of critical factors. Here’s a breakdown to help contextualize the potential costs:

---

💡 Quick Summary Estimates​

Type of Facility	Estimated Cost (USD)
Small-scale pilot plant (non-GMP)	$1M – $5M
Medium-scale GMP facility	$10M – $50M
Full-scale commercial GMP facility	$50M – $500M+
High-tech biologics facility (e.g. for mRNA, cell therapy)	$100M – $1B+

---

🧪 Key Cost Drivers​

1. Type of Drugs Produced
   • Tablets/capsules (solid dosage): Less expensive
   • Injectables/sterile products: Much more expensive (clean rooms, sterility)
   • Biologics or biosimilars: Extremely high-cost (fermentation, purification, cold chain)
   • Controlled substances: Higher security and regulatory needs
2. Production Scale
   • Pilot (R&D or clinical batches)
   • Mid-size (regional supply)
   • Full commercial scale (global supply)
3. GMP Compliance
   • Compliance with FDA, EMA, WHO, or local authorities can significantly increase costs.
4. Geographic Location
   • Labor, materials, utilities, and regulation costs vary by country.
   • Example: India or China might be 30–70% cheaper than the US or EU.
5. Infrastructure & Utilities
   • HVAC systems (especially for sterile environments)
   • Water-for-injection (WFI), clean steam, compressed air
   • Waste treatment, energy backup systems
6. Automation & Tech
   • Manual vs semi-automated vs fully automated lines
   • Use of robotics, AI for QC, or electronic batch records adds cost
7. Time to Build
   • 18 to 36 months is typical for a GMP-compliant facility

---

📊 Real-World Examples​

• Pfizer’s gene therapy plant (North Carolina, US): ~$600 million
• Biocon biologics facility (India): ~$275 million
• Generic oral solid dosage facility (India): $10–20 million
• Sterile injectable plant (EU): $50–150 million

---

💼 What’s Included in the Investment?​

• Facility design and construction
• HVAC, cleanroom systems
• Production equipment
• Quality control labs (analytical chemistry, microbiology)
• IT systems (LIMS, ERP)
• Regulatory and validation activities
• Hiring and training staff
• Licensing and inspections

---

✅ Bonus: Cost-Saving Options​

• Contract Manufacturing (CDMOs): Avoid CapEx altogether
• Modular/Prefab Facilities: Can reduce cost and time by 20–40%
• Refurbished Equipment: Often used by generics manufacturers
• Location Arbitrage: Set up in countries with lower regulatory and labor costs

---

Would you like a custom estimate based on a specific type of drug (e.g. tablets vs biologics) and country (e.g. US, India, etc.)?

Hayo madafu ya mama aache kubebea kenge kwnye matrekta kuwapaleka kwa mikutani yake kule uswekeni afanye investment ya hivi halafu "rais" ukafanye utafiti wako na kuzalishia mitishamba? Hebu kuwa serious kijana!

Hii ni AI haya tupe sasa wewe mtazamo wako binafsi katika huu mjadala.

 

[Lamine yamal UDOM]

Imagine hadi leo tunapambana na maralia kwa chandarua na dawa ya mseto au Metakelfin wakati ni ugonjwa unaoweza kutokomezeka kwa urahisi kabisa na kupunguza gharama kwa serikali na raia kwa asilimia 100%. Zero maralia inawezekana ila jamaa wanapambana kila siku maralia iendelee kusababisha vifo na mateso kwa watu.

Shenzi sana hawa.

aisee,hiki gwajima alikikazia kwenye video moja kwamba uwezo wa kutokomeza malaria tunao kabisa,na tuna kiwanda kabisa kiko mainland ila ndo hivyo tunaexport dawa tu *****,sitaki kuendelea manake napandwa na hasira.

 

[Ngwathra]

Hii ni AI haya tupe sasa wewe mtazamo wako binafsi katika huu mjadala.

Mimi ni mdau mwenye 25yrs experience, utafiti wa madawa na kuendesha kiwanda cha madawa sio kama stori za huyu kijana anazotoa kila siku hapa. Eti ana proposal ya utafiti wa Ebola na Marburg disease?? Viral?? anacheza huyu, unajua hata darubini ya kumuona virus haipo tz? Eti kapeleka kwenye taasisi wakamkatalia, sio kumkatalia tu angekua mtu seriuos angempeleka mirembe tu!

 

[Dennis Robert Shughuru]

Mimi ni mdau mwenye 25yrs experience, utafiti wa madawa na kuendesha kiwanda cha madawa sio kama stori za huyu kijana anazotoa kila siku hapa. Eti ana proposal ya utafiti wa Ebola na Marburg disease?? Viral?? anacheza huyu, unajua hata darubini ya kumuona virus haipo tz? Eti kapeleka kwenye taasisi wakamkatalia, sio kumkatalia tu angekua mtu seriuos angempeleka mirembe tu!

Mimi najua namna na njia ya kutengeneza dawa kuliko wewe unayetegemea AI na ndo akili zilizojaa huko kwenye hizo taasisi

Nyie ambao mko seriously nini cha maana mmefanya kwenye field life science so far hakuna cha maana mlifonya mnakula fedha na serikali na mishahara minono na hakuna cha maana mnachofanya miaka nenda rudi

Mkiulizwa maswali kama haya mnakuja na vitusho mara hiki gharama yake ni hiki au vile yaani mnatafuta vichaka vya kujificha kwa nguvu zote

 

[Dennis Robert Shughuru]

Hii ni AI haya tupe sasa wewe mtazamo wako binafsi katika huu mjadala.

Ndo akili kama hizi zimejaa huko kwenye taasisi imagine jambo la gharama za kuanzisha maabara tu mtu anaenda kucopy na kupaste AI